publications

주요실적

Membership

  1. Member in Society of Toxicology (2005. 5 - Present)
  2. Member in American Heart Association (2008. 8- Present)
  3. Committee member in Korean Society for Alternative to Animal Experiments (2013.1-Present)
  4. Committee member in Korean Society of Toxicology (2012.7-Present)
  5. Committee member in Korean Society of Environmental Health Toxicology (2012.1-Present)
  6. Committee member in Korean Society of Applied Pharmacology (2013.1-Present)
  7. Organizing committee member for International Congress for Toxicology2013 (2013)
  8. Organizing committee member for AsiaTox2015 (2015)
  9. Organizing committee member for International Conference of Mercury the Global Pollutant (ICMGP)2015 (2015)

Awards

  1. KIT-sponsored Award for Excellent Young Toxicologist from the Korean Society of Toxicology (2014.11)
  2. Award for Outstanding Junior Scientist from the Korean Society of Pharmaceutical Sciences (2014.10)
  3. Research Award for Post-doctoral Program from Korea Research Foundation, Korea (2007.11)
  4. Award for Excellent Poster Presentation from the Korean Society of Food Hygiene and Safety, Korea (2007.11)
  5. Excellent Achievement in Research and Education Program from Korea Science Academy, Korea (2007.3)
  6. Award for Excellent Poster Presentation from the Korean Society of Food Hygiene and Safety, Korea (2006.11)
  7. 2006 Travel Award from the Society of Toxicology, USA (2006.3)
  8. National Research Fellowships for Young Scientist from Korea Research Foundation, Korea (2005.12)
  9. Frontier in Thrombosis and Hematology by Young Asian Investigators from Japanese society of Thrombosis and Hemostasis, Japan (2005.10)
  10. Scholarship from Health and Science Scholarship Fund, Korea (2005.7)
  11. Excellent Research Award for Pre-doctoral Program from Korea Research Foundation, Korea (2004.11

Publications

SCI(E) Journal

  1. Akram M, Shin I, Kim KA, Noh D, Baek SH, Chang SY, Kim H, BAE ON (2016) A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: the Nrf2/heme oxygenase signaling as a potential target. Toxicol Appl Pharmacol. (In press)
  2. Akram M, Kim KA, Kim ES, Shin YJ, Noh D, Kim E, Kim JH, Majid A, Chang SY, Kim JK, Bae ON (2016) Selective inhibition of JAK2/STAT1 signaling and iNOS expression mediates the anti-inflammatory effects of coniferyl aldehyde. Chem Biol Interact. 256:102-110. (Epub ahead of print)
  3. Kang S, Kim K, Noh JY, Jung Y, Bae ON, Lim KM, Chung JH. (2016) Simvastatin induces the apoptosis of normal vascular smooth muscle through the disruption of actin integrity via the impairment of RhoA/Rac-1 activity. Thromb Haemost. 116(3) (Epub ahead of print)
  4. Kim CW, Park GT, Bae ON, Noh M, Choi KC. (2016) Application of SV40 T-transformed human corneal epithelial cells to evaluate potential irritant chemicals for in vitro alternative eye toxicity. J Pharmacol Toxicol Methods. 80:82-9.
  5. Akram M, Kim KA, Kim ES, Syed AS, Kim CY, Lee JS, Bae ON. (2016) Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway. Biol Pharm Bull. 39(5):728-36.
  6. Klionsky DJ, .. BAE ON,.. et al., (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222.
  7. Majid A, Bae ON, Redgrave J, Teare D, Ali A, Zemke D (2015) The Potential of Adaptive Design in Animal Studies. Int J Mol Sci.16 (10); 24048-58.
  8. Akram M, Shah Syed A, Kim KA, Soo Lee J, Chang SY, Young Kim C, Bae ON (2015) Heme oxygenase 1-mediated novel anti-inflammatory activities of Salvia plebeia and its active components. J Ethnopharmacol. 174; 322-330.
  9. Kim K, Bae ON, Koh SH, Kang S, Lim KM, Noh JY, Shin S, Kim I, Chung JH (2015). High-Dose Vitamin C Injection to Cancer Patients May Promote Thrombosis Through Procoagulant Activation of Erythrocytes. Toxicol Sci. 147(2); 350-9. Co-first author
  10. Kim SE, Park HJ, Jeong HK, Kim MJ, Kim M, Bae ON, Baek SH (2015). Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions. Biochem Biophys Res Commun. 463(3); 205-10.
  11. Kim ES, Lee JS, Akram M, Kim KA, Shin YJ, Yu JH, Bae ON (2015). Protective activity of Dendropanax morbifera against cisplatin-induced acute kidney injury. Kidney Blood Press Res. 40(1); 1-12.
  12. Bae ON, Ahn S, Jin SH, Hong SH, Lee J, Kim ES, Jeong TC, Chun YJ, Lee AY, Noh M (2015) Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor. Toxicol Appl Pharmacol. 283(2); 147-55.
  13. Bae ON, Noh M, Chun YJ, Jeong TC (2015). Keratinocytic vascular endothelial growth factor as a novel biomarker for pathological skin condition. Biomol Ther 23(1); 12-8.
  14. Lim YJ, Koo JE, Hong EH, Park ZY, Lim KM, Bae ON, Lee JY (2015). A Src-family-tyrosine kinase, Lyn, is required for efficient IFN-β expression in pattern recognition receptor, RIG-I, signal pathway by interacting with IPS-1. Cytokine. 72(1); 63-70.
  15. Kwon SY, Bae ON, Noh JY, Kim K, Kang S, Shin YJ, Lim KM, Chung JH (2015). Erythrophagocytosis of lead-exposed erythrocytes by renal tubular cells: possible role in lead-induced nephrotoxicity. Environ Health Perspect. 123(2); 120-7. Co-first author
  16. Baek SH, Noh AR, Kim KA, Akram M, Shin YJ, Kim ES, Yu SW, Majid A, Bae ON (2014) Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage. Stroke 45; 2438-2443
  17. Kim KA, Shin YJ, Akram M, Kim ES, Choi KW, Suh H, Lee CH, Bae ON (2014) High glucose condition induces autophagy in endothelial progenitor cells contributing to angiogenic impairment. Biol Pharm Bull 37; 1248-1252
  18. Yun JW, Kim M, Cho SD, Lee JY, Bae ON, Lim KM (2014) Highly expressed protein kinase A inhibitor α and suppression of protein kinase A may potentiate acetaminophen-induced hepatotoxicity. Toxicol Lett 229; 59-65
  19. Lee KY, Bae ON, Weinstock S, Kassab M, Majid A (2014) Neuroprotective effect of asiatic acid in rat model of focal embolic stroke. Biol Pharm Bull 37; 1397-1402
  20. Lim KM, Kwon JH, Kim K, Noh JY, Kang S, Park JM, Lee MY, Bae ON, Chung JH (2014) Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in isolated rat thoracic aorta. Br J Pharmacol 171; 4300-4310
  21. Hwang DH, Kim YI, Cho KH, Poudel BK, Choi JY, Kim DW, Shin YJ, Bae ON, Yousaf AM, Yong CS, Kim JO, Choi HG (2014) A novel solid dispersion system for natural product-loaded medicine: silymarin-loaded solid dispersion with enhanced oral bioavailability and hepatoprotective activity. J Microencapsul 31;619-626
  22. Kang S, Woo HH, Kim K, Lim KM, Noh JY, Lee MY, Bae YM, Bae ON, Chung JH (2014) Dysfunction of vascular smooth muscle and vascular remodeling by simvastatin. Toxicol Sci 138; 446-455
  23. Bae ON, Wang JM, Baek SH, Wang Q, Yuan H, Chen AF (2013) Oxidative Stress–Mediated Thrombospondin-2 Upregulation Impairs Bone Marrow–Derived Angiogenic Cell Function in Diabetes Mellitus. Arterioscler Thromb Vasc Biol 33; 1920-1927
  24. Yang KY, Hwang DH, Yousaf AM, Kim DW, Shin YJ, Bae ON, Kim YI, Kim JO, Yong CS, Choi HG (2013) Silymarin-loaded solid nanoparticles with excellent hepatic protection: physicochemical characterization and in vivo evaluation. Int J Nanomedicine 8;3333-3343
  25. Bae ON, Majid A (2013) Role of histidine/histamine in carnosine-induced neuroprotection during ischemic brain damage. Brain Res 1527; 246-254
  26. Baek SH, Bae ON, Kim EK, Yu SW (2013) Poly(ADP-ribose) polymer induces mitochondrial dysfunction and apoptosis-inducing factor release for cell death. Mol Cells 36; 258-266 * co-first author
  27. Kim K, Lim KM, Shin HJ, Seo DB, Noh JY, Kang S, Chung HY, Shin S, Chung JH, Bae ON (2013) Inhibitory effects of black soybean on platelet activation mediated through its active component of adenosine. Thromb Res 131; 254-261
  28. Bae ON, Serfozo K, Baek SH, Lee KY, Dorrance A, Rumbeiha W, Fitzgerald SD, Farooq MU, Naravelta B, Bhatt A, Majid A (2013) Safety and efficacy evaluation of carnosine, a neuroprotective agent against ischemic stroke. Stroke 44; 205-212
  29. Kim K, Bae ON, Lim KM, Noh JY, Kang S, Chung KY, Chung JH (2012) Novel anti-platelet activity of protocatechuic acid through inhibition of high shear stress-induced platelet aggregation. J Pharmacol Exp Ther 343; 704-711
  30. Bae ON, Rajanikant K, Min J, Smith J, Baek SH, Serfozo K, Hejabian S, Lee KY, Kassab M, Majid A. (2012) Lck activation mediates neuroprotection during ischemic preconditioning. J Neurosci 32; 7278-7286
  31. Bae ON (2012) Targeting von Willebrand factor as a novel antiplatelet therapy; application of ARC1779, an anti-vWF aptamer, against thrombotic risk. Arch Pharm Res 35; 1693-1699
  32. Kim KA, Shin YJ, Kim JH, Lee H, Noh SY, Jang SH, Bae ON (2012) Dysfunction of endothelial progenitor cells under diabetic conditions and its underlying mechanisms. Arch Pharm Res 35; 223-234
  33. Song JS, Lim KM, Kang S, Noh JY, Kim K, Bae ON, Chung JH (2012) Procoagulant and prothrombotic effects of herbal medicine, Dipsacus asper and its active ingredient, dipsacus saponin C, on human platelets. J Thromb Haemost 10; 895-906
  34. Lee KY, Bae ON, Serfozo K, Hejabian S, Moussa A, Reeves M, Rumbeiha W, Fitzgerald SD, Stein G, Baek SH, Goudreau J, Kassab M, Majid A (2012) Asiatic Acid Attenuates Infarct Volume, Mitochondrial Dysfunction and Matrix Metalloproteinase-9 Induction after Focal Cerebral Ischemia. Stroke 43; 1632-1638
  35. Baek SH, Bae ON, Park JH (2012) Recent Methodology in Ginseng Analysis. J Ginseng Res 36; 119-134
  36. Baek SH, Lee JG, Park SY, Piao XL, Kim HY, Bae ON, Park JH (2012) Gas chromatographic determination of azetidine-2-carboxylic acid in rhizomes of Polygonatum sibiricum and P. odoratum. J Food Comp Anal 25; 137–141
  37. Min J, Yu SW, Baek SH, Nair KM, Bae ON, Bhatt A, Kassab M, Nair MG, Majid A (2011) Neuroprotective Effect of Cyanidin-3-O-glucoside Anthocyanin in Mice with Focal Cerebral Ischemia Neurosci Lett 500;157-161
  38. Kim K, Lim KM, Kim CW, Shin HJ, Seo DB, Lee SJ, Noh JY, Bae ON, Shin S, Chung JH (2011) Black soybean extract can attenuate thrombosis through inhibition of collagen-induced platelet activation. J Nut Biochem 22:964-70
  39. Jun EA, Lim KM, Kim K, Bae ON, Noh JY, Chung KH, Chung JH (2011) Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity. Nanotoxicology 5;157-167
  40. Lee JY, Lim KM, Kim SY, Bae ON, Noh JY, Chung SM, Kim K, Shin YS, Lee MY, Chung JH (2010) Vascular smooth muscle dysfunction and remodeling induced by ginsenoside Rg3, a bioactive component of ginseng. Toxicol Sci 117:505-514
  41. Baek SH, Lee JG, Park SY, Bae ON, Kim DH, Park JH (2010) Pectic polysaccharides from Panax Ginseng as the anti-rotavirus principals in ginseng. Biomacromolecules 11; 2044-2052
  42. Noh JY, Park JS, Lim KM, Kim K, Bae ON, Chung SM, Shin S, Chung JH (2010) Procoagulant and prothrombotic activation of human erythrocyte by phosphatidic acid. Am J Physiol Heart Circ Physiol 299; H347-355
  43. Lim KM, Kim S, Noh JY, Kim K, Jang WH, Bae ON, Chung SM, Chung JH (2010) Low-level of Mercury Enhances Procoagulant Activity of Erythrocytes: A New Contributing Factor for Mercury-related Thrombotic Disease. Environ Health Perspect 118; 928-935
  44. Noh JY, Park JS, Lim KM, Kim K, Bae ON, Chung SM, Shin S, Chung JH (2010) A naphthoquinone derivative can induce anemia through phosphatidylserine exposure mediated erythrophagocytosis. J Pharmacol Exp Ther 333; 141-420
  45. Bae ON, Lim KM, Noh JY, Chung SM, Kim SH, Chung JH (2009) Trivalent methylated arsenical-induced PS exposure and apoptosis in platelets may lead to increased thrombus formation. Toxicol Appl Phamacol 239; 144-153
  46. Lim KM, Kim HH, Bae ON, Noh JY, Kim KY, Kim SH, Chung SM, Shin S, Kim HY, Chung JH (2009) Inhibition of platelet aggregation by 1-methyl-4-phenyl pyridinium ion (MPP+) through ATP depletion: Evidence for the reduced platelet activities in Parkinson's disease. Platelets 20;163-170
  47. Kim EJ, Lim KM, Kim KY, Bae ON, Noh JY, Chung SM, Shin S, Yun YP, Chung JH (2009) Doxorubicin-induced platelet cytotoxicity: a new contributing factor to doxorubicin-mediated thrombocytopenia. J Thromb Haemost 7; 1172-1183
  48. Lim KM, Lee JY, Lee SM, Bae ON, Noh JY, Kim EJ, Chung SM, Chung JH (2009) Potent anti-inflammatory effects of novel quinolinedione derivatives, OQ1 and OQ21 mediated by dual inhibition of iNOS and COX-2. Brit J Pharmacol 156; 328-337
  49. Bae ON, Lim EK, Lim KM, Noh JY, Chung SM, Lee MY, Yun YP, Kwon SC, Lee JH, Nah SY, Chung JH (2008) Vascular Smooth Muscle Dysfunction Induced by Monomethylarsonous Acid (MMAIII): A Contributing Factor to Arsenic-associated Cardiovascular Diseases. Environ Res 108; 300-308
  50. Bae ON, Lim KM, Han JY, Jung BI, Lee JY, Noh JY, Chung SM, Lee MY, Lee JY, Chung JH (2008) U-shaped dose response in vasomotor tone: A mixed result of heterogenic response of multiple cells to xenobiotics. Toxicol Sci 103: 181-190
  51. Bae ON, Kim YD, Lim KM, Noh JY, Chung SM, Kim K, Hong S, Shin S, Yoon JH, Chung JH (2008) Salsolinol, an endogenous neurotoxin, enhances platelet aggregation and thrombus formation. Thromb Haemost 100: 52–59
  52. Lim KM, Kim JS, Bae ON, Noh JY, Chung SM, Chung KY, Chung JH (2008) Co-oxidation-mediated xenobiotic activation and cytotoxicity by 12-lipoxygenase in intact platelets. Toxicology. 247:154-160
  53. Bae ON, Lim KM, Noh JY, Chung SM, Kim H, Lee CR, Park JD, Chung JH (2007) Arsenite enhanced procoagulant activity through phosphatidylserine exposure in platelets. Chem Res Toxicol 20: 1760-1768
  54. Chung SM, Bae ON, Lim KM, Noh JY, Lee MY, Jung YS, Chung JH (2007) Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes. Arterioscler Thromb Vasc Biol 27: 414-421
  55. Shin JH, Lim KM, Noh JY, Bae ON, Chung SM, Lee MY, Chung JH (2007) Lead-induced procoagulant activation of erythrocytes through phosphatidylserine exposure may lead to thrombotic diseases. Chem Res Toxicol 20: 38-44
  56. Chung KY, Lim KM, Chung SM, Lee MY, Noh JY, Bae ON, Chung JH (2006) Shear stress induced pH increase in plasma is mediated by PCO2 decrease and pH increase alone can enhance shear stress induced P-selectin expression in platelets. Platelets 17: 127-133
  57. Lee MY, Lee YH, Lim KM, Chung SM, Bae ON, Kim H, Lee CR, Park JD, Chung JH (2005) Inorganic Arsenite potentiates vasoconstriction through calcium-sensitization in vascular smooth muscle Environ Health Perspect 113: 1330-1335
  58. Chung KY, Lee SJ, Chung SM, Lee MY, Bae ON, Chung JH (2005) Generation of free radical by interaction of iron with thiols in human plasma and its possible significance. Thromb Res 116: 157-164
  59. Lee MY, Jung BI, Chung SM, Bae ON, Lee JY, Park JD, Yang JS, Lee H, Chung JH (2003) Arsenic-induced dysfunction in relaxation of blood vessels. Environ Health Perspect 111: 513-517
  60. Kang KT, Jung BI, Bae ON, Lee MY, Chung SM, Lee JY, Lee SK, Kim IC, Chung JH (2003) Antithrombotic activity of LB30057, a newly synthesized direct thrombin inhibitor. Thromb Haemost 89: 104-111
  61. Bae ON, Lee JY, Chung GY, Chung SM, Lee MY, Yun YP, Kim YC, Moon CK, Chung JH (2003) Enhanced menadione cytotoxicity in platelets isolated from streptozotocin-induced diabetic rats. Thromb Res 111: 179-183
  62. Lee SK, Chung SM, Lee MY, Lee JY, Bae ON, Chung JH (2002) The roles of ATP and calcium in morphological changes and cytotoxicity induced by 1,4-benzoquinone in platelets. Biochim Biophys Acta 1569: 159-166
  63. Jung BI, Kang KT, Bae ON, Lee MY, Chung SM, Lee SK, Kim IC, Chung JH (2002) LB30057 inhibits platelet aggregation and vascular relaxation induced by thrombin. Arch Pharm Res 25: 879-884
  64. Lee MY, Bae ON, Chung SM, Kang KT, Lee JY, Chung JH (2002) Enhancement of platelet aggregation and thrombus formation by arsenic in drinking water: a contributing factor to cardiovascular disease. Toxicol Appl Pharmacol 179: 83-88
  65. Kang YA, Bae ON, Lee MY, Chung SM, Lee JY, Chung JH (2002) Temperature-dependent quinone cytotoxicity in platelets involves arylation. J Toxicol Environ Health A 65: 1367-1378
  66. Lee JY, Bae ON, Chung SM, Lee MY, Chung JH (2001) Menadione induces endothelial dysfunction mediated by oxidative stress and arylation. Chem Biol Interact 137: 169-183
  67. Kim SR, Lee JY, Lee MY, Chung SM, Bae ON, Chung JH (2001) Association of quinone-induced platelet anti-aggregation with cytotoxicity. Toxicol Sci 62: 176-182
  68. Chung SM, Lee JY, Lee MY, Bae ON, Chung JH (2001) Adverse consequences of erythrocyte exposure to menadione: involvement of reactive oxygen species generation in plasma. J Toxicol Environ Health A 63: 617-629

Korean Journal

  1. Bae ON, Lee JY (2016) Shedding New Lights with the Breakthrough Ideas to Understand Current Trends in Modern Toxicology. Toxicological research 32(1):1-3.
  2. Kim JH, Byun HM, Chung EC, Chung HY, Bae ON. (2013) Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke. Toxicological research 29(3):157-64.
  3. Bae ON, Lim KM, Noh JY, Kim K, Lim EK, Chung JH (2008). Methylated organic metabolites of arsenic and their cardiovascular toxicities. Toxicological research 24; 161-167
  4. Chung SM, Bae ON, Noh JY, Kim SJ, Lim KM, Chung JH (2006). Microvesicle generation by lipid mediator in erythrocytes. Journal of Toxicology and Public Health 22; 397-402
  5. Bae ON, Lee MY, Chung SM, Ha JH, Chung JH (2006). Potential risk to human health by arsenic and its metabolites (Review). Journal of Environmental Toxicology 21: 1-11
  6. Kim YD, Bae ON, Chung SM, Chung JH (2004). Improvement of hemostasis mediated by anti-platelet activities by plant vinegar. Journal of Toxicology and Public Health 20; 137-142
  7. Jew SS, Bae ON, Chung JH (2003). Anti-inflammatory effects of asiaticoside on inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cell line. Journal of Toxicology and Public Health 19: 33-37
  8. Lee SK, Bae ON, Chung JH (2003). Effect of extracellular calcium on menadione-induced cytotoxicity in platelets. Journal of Environmental Protection and Safety 16: 1-6
  9. Lee SK, Bae ON, Kang KT, Lee JY, Ryu CK, Kim HJ, Chung JH (1999). Effect of quinolinedione derivative on blood vessels and its acute toxicity. Journal of Food Hygiene and Safety 14: 282-286
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